Pruritus gravidarum, a specific dermatosis of pregnancy, is a condition of the skin in gravid women represented by itching and only secondary lesions in the form of excoriations with or without evidence of cholestasis Pruritus affects up to 20% of pregnant women. 1,2 Pruritus can be sufficiently severe to affect sleep and quality of life, and might lead to or worsen depression. 3 Although it is commonly caused by dry skin, it can also indicate an underlying condition unique to pregnancy. The dermatoses of pregnancy include pruritic urticarial papules and plaques of pregnancy (PUPPP), intrahepatic. The management of a patient with pruritus gravidarum requires an interprofessional team consisting of an obstetrician, dermatologist, hepatologist, maternal-fetal medicine specialist, and the nursing team. The management team must focus on making the patient as comfortable as possible while monitoring the fetus of any complications Pruritus is the subjective sensation of itching. It can become severe enough to interfere with work and restful sleep. Histamine is the primary mediator of itching in many disorders.1.
No specific treatment is available. However, the aim of the treatment is to reduce bile acid levels in serum. 1. Ursodeoxycholic acid (Triptor) is considered as treatment of choice as it offers the following benefits: Improves maternal pruritus 13. Price TJ, Patterson WK, Olver IN. Rifampicin as treatment for pruritus in malignant cholestasis. Support Care Cancer 1998; 6(6): 533-535. 14. Silva SRT, Viana PC, Lugon NV, Hoette M, Ruzany F, Lugon JR. Thalidomide for the treatment of uraemic pruritus. A cross over randomized double-blind trial. Nephron 1994; 67(3): 270-273
To relieve itching, place a cool washcloth or some ice over the area that itches, rather than scratching. Your doctor may also prescribe medication to treat pruritus, including antihistamines and.. Pruritus is the medical term for itch. Itch is an unpleasant sensation on the skin that provokes the desire to rub or scratch the area to obtain relief. Itch can cause discomfort and frustration; in severe cases it can lead to disturbed sleep, anxiety and depression. Constant scratching to obtain relief can damage the skin ( excoriation. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 July 2021), Cerner Multum™ (updated 1 July 2021), ASHP (updated 30 June. Pruritus gravidarum usually resolves soon after delivery but may develop with subsequent pregnancies or with oral contraceptive ingestion . Pruritus in intrahepatic cholestasis of pregnancy is characterized by pruritus and elevated levels of bile acids, and it carries a high risk of adverse perinatal outcome [ 39 ] Prurigo of pregnancy is a benign non-specific pruritic (itchy) papular rash that arises during pregnancy. Prurigo of pregnancy has been described using a number of names including prurigo gestationis, early onset prurigo of pregnancy, papular dermatitis of pregnancy, and pruritic folliculitis of pregnancy
Pruritus gravidarum (PG) is a generalized, severe itchiness of late pregnancy where the only skin lesions are those secondary to scratching [74, 88]. It is uncertain whether it is an extension of the physiologic changes (pregnancy is cholestatic)  or a specific der-matosis [1, 88] Pruritus may also appear as a prominent feature of extracutaneous disorders, such as systemic, neurologic, and psychiatric diseases ( table 2 ). The pathogenesis and etiology of pruritus, as well as the evaluation of the patient with pruritus, will be reviewed here. The treatment of pruritus is discussed separately Review the appropriate history, physical, and evaluation of pruritus gravidarum. Outline the treatment and management options available for pruritus gravidarum. Summarize interprofessional team strategies for improving care coordination and communication to improve outcomes in pruritus gravidarum Pregnancy Pruritus gravidarum Drug-induced pruritus (selection) Opioids, ACE-inhibitors, amiodarone, hydrochlorothiazid, •The current guidelines for the treatment of pruritus recommend a step-by-step treatment procedure, tailored to the severity of symptoms, accompanying diseases, patient´
pruritus gravidarum A condition characterized by intense itching, which occurs in 1:300 pregnancies, beginning in the 3 rd trimester, first on the abdomen, later extending to the entire body surface Treatment Antihistamines This disorder should not be confused with pruritus gravidarum (itching during pregnancy). atopic eruption of pregnancy is a benign pruritic disorder of pregnancy which includes eczematous and/or papular lesions in patients with an atopic diathesis after exclusion of the other dermatoses of pregnancy Furthermore, both intrahepatic cholestasis and extrahepatic biliary blockage can cause pruritus. Primary Biliary Cirrhosis (PBC), cholestasis during pregnancy (pruritus gravidarum), drug-induced cholestasis, and viral hepatitis are all intrahepatic cholestasis processes linked to pruritus. Cholestatic Pruritus Pipeline Analysis: Drug Profil
Pruritus gravidarum might be both localized, affecting mainly breasts and abdomen, and generalized. It may accompany the specific dermatoses of pregnancy, although it can also occur without any underlying disease. further studies are needed to better characterize this subset of patients and determine the best treatment options. Disclosure Stokke G, Gjelsvik BL, Flaatten KT, et al. Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study. Acta Obstet Gynecol Scand 2015; 94:359. Peled Y, Melamed N, Hiersch L, et al. The impact of total parenteral nutrition support on pregnancy outcome in women with hyperemesis gravidarum The presenting symptom of ICP is pruritus (skin), and diagnosis is confirmed by demonstration of raised total serum bile acids. However, maternal pruritus without hepatic impairment or dermatological disorder (i.e., pruritus gravidarum [PG]) affects up to 25% of pregnant women, 3, 4 while ICP is much less common Pruritus gravidarum Pruritus in 3rd trimester No abnormal laboratory values Atopic eruption Pruritus in 1st trimester Dry, red rash on trunk and limbs Pruritic urticarial papules and plaques of pregnancy (PUPPS) Pruritus in 3rd trimester Papules, plaques, or vesicles in striae, sparing umbilicu
Nevertheless, several mechanisms have been proposed: pruritus connected with a central/peripheral origin, itch caused by mast cells' hyperactivity, or determined by the intrahepatic cholestasis of pregnancy. This article concentrates on the pruritus accompanying advanced liver disorders. Its pathogenesis and treatment are also discussed Itch subsides with treatment (Bernhard, 1994). Chronic liver disease, including viral hepatitis, cirrhosis, pruritus gravidarum (cholestasis of pregnancy), and drug-induced cholestasis, can be accompanied by obstructive jaundice and pruritus, termed as cholestatic pruritus (Bernhard, 1994) tional pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to benign pruritus gravidarum. ICP is characterized by raised serum bile acids and complicated by spontaneous preterm labor and stillbirth. A biomarker for ICP would be invaluable for early diagnosis and treatment and to enable its differentia severe, they are diagnosed with 'Pruritus Gravidarum'. (Table 1, Figure 1) -If the patient < 32 wks with prior severe pruritus has already been started on ursodiol for 'Severe Pruritus of Pregnancy', but has normal labs q wk x2, then discontinue the ursodiol and continue weekly labs Treatment of Pemphigoid Gestationis (PG) Relieve itching with antihistamine; Prevent blister formation with topical or oral steroids; In severe patients, immunosuppression may be needed; Secondary infection is treated; 4. Intrahepatic Cholestasis of Pregnancy (ICP) Also known as. Pruritus Gravidarum; Obstetic cholestasis; Affects 0.02-2.4 % of.
Hyperemesis gravidarum is the spectrum of severe vomiting that results in weight loss (>5%), ketonuria, electrolyte abnormalities (hypokalemia, alkalosis from loss of hydrochloric acid), and dehydration (high urine specific gravity) that are unresponsive to dietary modifications and medications Pruritus gravidarum was associated with higher rates of labor inductions (OR=5.6; 95% CI 4.6-6.9), and accordingly were more likely to be delivered by cesarean deliveries (OR=2.8; 95% CI 2.3-3.5).CONCLUSION: Pruritus gravidarum, associated with multiple gestations, fertility treatments, diabetes mellitus and nulliparity, has a favorable. Peter Braude, Diana Hamilton-Fairley, in Obstetric and Gynecologic Dermatology (Third Edition), 2008. Striae gravidarum. Striae gravidarum are linear purple-red lesions which over time lose their pigmentation and atrophy, leaving scar-like tissue. They can cause itching and discomfort and affect 50-90% of women during pregnancy. The underlying etiology has always been unclear, with two. Pruritus gravidarum. Pregnant woman itchy feet. Credit: Jose Luis Pelaez/Getty Images. Treatment for cancer, like chemotherapy and radiation, can cause itching too, Dr. Cotton adds Pruritus is often the most troublesome symptom in patients with chronic liver disease, particularly when cholestasis is a prominent feature. The exact pathogenesis is unknown, but empirical treatment, such as cholestyramine, based on a liver‐based origin of pruritus, has been used for many years
Itch levels were evaluated using the visual analog scale (VAS). The severity of pruritus in the treatment group was significantly lower than in the placebo group. Peppermint oil can thus be effective in reducing the severity of Pruritus gravidarum, or pregnancy itch. There is no indication that Peppermint oil carries any risk in pregnancy Pruritus 1. +PRURITU S PRESENTER: DR. KEZHALETO MODERATOR: DR. ANANTA 2. +INTRODUCTION Pruritus can be defined as an uncomfortable sensation and emotional experience associated with an actual or perceived disturbance to the skin that provokes the desire to scratch. Chronic pruritus is defined as pruritus lasting more then 6 weeks The sensation of itch was first described in 1893 by Radcliffe.
Pruritus gravidarum was associated with higher rates of labor inductions (OR=5.6; 95% CI 4.6-6.9), and accordingly were more likely to be delivered by cesarean deliveries (OR=2.8; 95% CI 2.3-3.5). Conclusion Pruritus gravidarum, associated with multiple gestations, fertility treatments, diabetes mellitus and nulliparity, has a favorable. In dermatology it is successfully used for the treatment of pruritus gravidarum ( off-label use). Other indications include the therapy of gallstones, biliary reflux gastritis and the symptomatic treatment of primary biliary cirrhosis. Furthermore: non-obstructive cholestatic diseases, especially PBC and PSC. Drug-induced liver damage. Hepatitide From a maternal viewpoint, the main consideration is intense pruritus, which may become so intolerable that delivery is considered as early as 35-37 weeks. The fetal viewpoint is more concerning, as even with modern treatment the risk for fetal demise can range from 2-11 %. Thus, many would advocate induction at 37 weeks Itch occurs in about one in five pregnant women. Obstetric cholestasis is the main cause of itch without a rash in pregnancy. The itch (often severe) usually starts abruptly in the third trimester, is often more noticeable on the soles and palms but can occur anywhere on the body, and may be worse at night The incidence of pruritus increases with age (1) and is one of the most common complaints in the elderly patient population. Most often dry skin, otherwise known as xerosis is the commonest cause in these patients (3). Reference: (1) Twycross R et al. Itch: scratching more than the surface. Q J Med 2003; 96: 7-26 (2) Moses S. Pruritus
Stretch marks, also known as Striae or Striae distensae, are a form of scarring on the skin with an off-color hue. Over time they may diminish, but will not disappear completely. Stretch marks are caused by tearing of the dermis during periods of rapid growth of the body, such as during puberty or pregnancy.In pregnancy they usually form during the last trimester, and usually on the belly, but. . Intrahepatic cholestasis processes associated with pruritus include Primary Biliary Cirrhosis (PBC), and cholestasis of pregnancy (pruritus gravidarum), drug-induced cholestasis, and viral hepatitis lestasis of pregnancy and pruritus gravidarum. METHODS: Plasma lipid concentrations were assessed in nonfasting blood samples from 63 women with intrahepatic cholestasis of pregnancy (n = 54, recruited at the time of diagnosis, and n = 9, who later developed the disease), 43 women with pruritus gravidarum, and 26 healthy pregnant controls during pregnancy and at 4-6 weeks postpartum. RESULTS. The presenting symptom of ICP is pruritus (skin), and diagnosis is confirmed by demonstration of raised total serum bile acids. However, maternal pruritus without hepatic impairment or dermatological disorder (i.e., pruritus gravidarum [PG]) affects up to 25% of pregnant women,3, 4 while ICP is much less common
A challenge in obstetrics is to distinguish pathological symptoms from those associated with normal changes of pregnancy, typified by the need to differentiate whether gestational pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to benign pruritus gravidarum. ICP is characterized by raised serum bile acids and complicated by spontaneous preterm. . Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology. 2015 Oct The possible role of estrogens in the pathogenesis of pruritus gravidarum and cholestatic jaundice of pregnancy was examined. 13 women of childbearing age who had been studied during at least 1 of their previous pregnancies were the subjects in the investigation. 7 of these women had symptoms during pregnancy; 3 had pruritus gravidarum and 4 cholestatic jaundice. 6 women who had been free of. itch [ich] a skin condition accompanied by the desire to scratch an area of skin to relieve discomfort; see also pruritus. bakers' itch any of several inflammatory dermatoses of the hands and forearms, especially chronic candidal paronychia, seen with special frequency in bakers. barbers' itch 1. sycosis barbae. 2. tinea barbae. 3. pseudofolliculitis.
Define pruritus. pruritus synonyms, pruritus pronunciation, pruritus translation, English dictionary definition of pruritus. n. Severe itching, often of undamaged skin. pru·rit′ic adj. American Heritage® Dictionary of the English Language, Fifth Edition Itch is a common symptom in the general population, and its prevalence increases with age. Assessment of a person with widespread itch should include: Asking about the characteristics of itch, associated sensory symptoms, impact on quality of life and associated psychological conditions, associated systemic symptoms, comorbidities, treatments. . It affects 0.7% to 5% of pregnancy in multiethnic population. Prevalence of ICP is influenced by genetic and environmental factors. It is a multi factorial condition of pregnancy character-ized by pruritus in the absence of a skin rash with abnormal live
Between 0.02 and 2.4% of pregnant women are diagnosed with a condition called pruritus gravidarum (also called PUPPS) or pruritic urticarial papules and plaques (PUPPP), a kind of severe itching with itchy red spots spreading to your arms and legs Pruritus is defined as an unpleasant sensation of the skin leading to the desire to scratch (1). Chronic pruritus, which can be distres-sing and often refractory to treatment, is associated with many diseases, the most common being chronic renal insufficiency, cholestatic liver diseases and atopic der- Pregnancy Pruritus gravidarum with. striae,11 and treatment of striae alba (mature stretch marks) with two different topical regimens (20% glycolic acid, 10% l-ascorbic acid, 2% zinc sulfate, and 0.5% tyrosine vs 20% glycolic acid, and 0.05% tretinoin emollient cream [Renova]).12 Treatment with laser and treatment with glycolic acid in combination with 0.05% tretinoin emollien
. Third trimester. Sudden onset of intense pruritus Often starts on palms or soles, then becomes generalized Only secondary skin changes from scratching are apparent: Elevated total serum bile acid level • Understand a basic systemic approach to pruritus in • Acne gravidarum • Tends to flare in early pregnancy but otherwise often improves • Montgomery gland enlargement • Prednisolone is treatment of choice -inactivated in the placenta • Recommended dosing: 0.5 mg/kg daily.
These concentrations were (weakly) associated with itch severity and were able to differentiate between women with ICP compared to those with benign pruritus gravidarum . One of these progesterone sulfates, 5β-pregnan-3α,-20α-diol-3-sulfate (PM3S), evoked a Tgr5-dependent scratch response in mice ( 156 ) Pruritus gravidarum, which sometimes accompany cholestasis during pregnancy. Polycythemia Rubra Vera; The publication 1,801 Home Remedies, shows that treatment of your itchy foot sole can be cured by prescriptions that heal any serious condition including athlete's foot pruritus gravidarum during pregnancy (it may or may not have accompanying cholestasis) Skin conditions allergic contact dermatitis , which can be caused by something like new laundry detergen
Pruritus, known colloquially as itch, is an unpleasant sensation that causes an urge to scratch. 1,2 It is a very common condition, with almost one-third of the global population experiencing itch. Depending on your genes, hormones, and rate of weight gain you may be more or less prone to developing stretch marks (striae gravidarum). Stretch marks can be a source of itching. Stretch marks. Obstetric cholestasis (Pruritus gravidarum) The incidence is higher in Scandinavia, Chile and China, family history in 35 %. Starts in the second half of pregnancy usually in the third trimester. Diagnosis: Pruritus without rash, worse at palms of hands and soles of feet. Mild elevated transaminase 3 fold very seldom up to 10 fold. Alkaline. Striae gravidarum (stretch marks) are considered the most common connective tissue/skin change in pregnancy. Though not a health issue they can affect women in different ways, for example, cause stress or be an aesthetic or cosmetic concern. Many women use one or more of the commercially available products to try and prevent their development during pregnancy despite the fact that that there. Cholestasis related pruritus is most severe at night, with a predilection for the hands and feet. It affects as many as 0.5% of pregnant women, particularly during the third trimester.7 Pruritus gravidarum usually resolves soon after delivery, but may develop with subsequent pregnancies or with oral contraceptive ingestion.
1) glucagon releasing peptide in lamina 1 of dorsal horn of SC, 2) Substance P (NK-1 receptors) 3) opioid peptides. Pruritis transmitted in epidermis by ____ and ______. C-fibers and. Delta neuron terminals. Dematologic causes of Pruritus w/ no or little skin findings. 1) Xerosis-dry skin. 2) Dermatographia- gentle skin stroking with finger or. Dry, Itchy Skin During Pregnancy - Prevention and Treatment. 1)Use lukewarm or cool water for showering, avoid chlorinated water. 2)Use mild, non-irritating soaps. 3)After showering, towel yourself and apply a moisturizing cream while your skin is still moist Creams or oils (such as vitamin E oil) or other treatments have not been shown to prevent stretch marks. They do, however, help with skin dryness and may reduce itching. Although stretch marks never go away, they fade to a lighter color, becoming less obvious after pregnancy. Itchy skin. Dry, stretching skin tends to be itchy Generalized pruritus is present in 1-8% of pregnant women (45). This pruritus gravidarum must be differentiated from pruritic dermatoses in pregnancy, such as pemphigoid gestationis (herpes gestationis), papular and pruritic dermatosis of pregnancy and others (46). Pruritus gravidarum was described together with jaundice by Kehrer in 1907 (47)
Pruritus without obvious dermatological cause is often the result of cholestasis of pregnancy. This condition shows itselfin morepronouncedcases byclinical jaundice, butin its milder form generalized itching may be the only symptom. The terms obstetric cholestasis,2 recurrent jaundice ofpreg-nancy,3 pruritus gravidarum,4 and idiopathic jaundice o Physiology. Related to Stretching with pregnancy. Deep collagen deposits break apart. Also associated with increased ACTH secretion. Affects connective tissue. Signs. Red, pink, or purple depressed atrophic bands, streaks. Distribution (occurs in areas of higher fat) Abdomen There is insuffi cient evidence to support routine testing for and treatment of H. pylori in asymptomatic individuals with a family history of gastric cancer or patients with lymphocytic gastritis, hyperplastic gastric polyps, and hyperemesis gravidarum (no recommendation; very low quality of evidence) pruritus gravidarum. Hepatology 2016; 63(4):1287-1298. 5. Abu-Hayyeh S, Williamson C. Progesterone metabolites as farnesoid X receptor inhibitors. Dig Dis 2015; 33(3):300-306. 6. Abu-Hayyeh S, Papacleovoulou G, Lovgren-Sandblom A, Tahir M, Oduwole O, Jamaludin NA et al. Intrahepatic cholestasis of pregnancy levels of sulfated progesterone.
Pruritus gravidarum—common in the first and second trimester (affects 1 in 5 women) Hair changes—telogen effluvium (post partum) Nail changes—ridging, splitting, distal onycholysis, longitudinal melanonychia. Vascular changes—telangectasia, varicosities, pyogenic granulomas, haemangiomas, peripheral oedem What Are The Complications Of Hyperemesis Gravidarum (HG)? Although numerous depending on individual biochemistry, severity of symptoms, and medical interventions, many potential complications may result from HG.If care is inadequate, ineffective, or delayed, cases of morning sickness or mild HG may progress to moderate or severe HG 2) Itching. Severe itching of the skin can occur during pregnancy (pruritus gravidarum) in 1-8% of pregnant women. Most pregnant women avoid using synthetic drugs because of their potential side effects for the baby. The use of peppermint oil may be a safe alternative for treating severe itching Pruritus is the main cutaneous symptom during pregnancy. Pruritus gravidarum refers to the intense itching that occurs late in pregnancy in the absence of any associated rash or clinical jaundice. The term prurigo of pregnancy or prurigo gestationis was first introduced by Besnier in 1904 to include all patients with pregnancy rash other than. Striae gravidarum, or stretch marks, occur commonly on the abdomen, thighs, and buttocks of pregnant women. These appear as atrophic, wrinkled, erythematous, purplish bands that fade only slightly over time (Fig. 6). Striae occur in 90% of fair-skinned individuals, usually in the third trimester of pregnancy
ICP is also referred to as choleastais of pregnancy and pruritus gravidarum. What causes ICP? There is still much to be learned about the exact causes of ICP and it's manifestation, but researchers are currently investigating genetic, hormonal and environmental factors The invention relates to a drug or a dermatological composition containing an avocado peptide extract for treating and/or preventing pruritus, in particular gravidic pruritus, pruritus sine materia, pruritus in newborns, and pruritus originating from a drug
Nausea during pregnancy is normal and common. But if you're throwing up multiple times a day, vomiting associated with ketosis and weight loss, and feel very sick, you might have a rare disorder called hyperemesis gravidarum.Only 0.5% to 2% of pregnant women get it.. This article explains what the illness is, causes, what the signs are, and how it's treated We conducted a study including 80 patients matched with 73 historical controls with severe hyperemesis gravidarum. 2 Control patients had received various antiemetic therapies, but not droperidol. Intervention patients were treated with intravenous hydration and droperidol 1.0-2.5 mg as an intravenous loading dose over 15 minutes, dependent upon severity of the patient's symptoms, followed by. The skin on the belly area can become itchy during pregnancy and creams and oils may help with this. Pregnancy is also responsible for an itch known as pruritus gravidarum
Itching during pregnancy is a common symptom. What many women don't realize, however, is that sometimes itching can be a sign of a liver abnormality called intrahepatic (within the liver) cholestasis (pooling of bile salts) of pregnancy. When associated with itching, the skin component is called pruritus gravidarum Striae usually result from continuous and progressive stretching of the skin, such as in pregnancy, adolescence, obesity and body builders. Striae may also result from the prolonged use of topical or oral corticosteroids. Rarely, striae can result from an underlying condition: Cushing's syndrome (obesity with distribution around the abdomen and. Ursodeoxycholic acid (UDCA) treatment (> or =21 days, n=15) significantly reduced serum taurocholic and taurodeoxycholic acid concentrations (P<0.01). Bile acid profiles were similar in normal pregnancy and pregnancy associated with pruritus gravidarum
Introduction Hyperemesis gravidarum (HG) is said to occur when early pregnancy is complicated by excessive vomiting that leads to electrolyte imbalance, ketosis or loss of more than 5% of the bodyweight. It can be accompanied by deranged liver function tests (LFT), and most patients recover uneventfully with no fetal harm. Methods A retrospective study was conducted by evaluating records of. Nausea and vomiting of pregnancy (NVP) affects 50-90% of pregnant women 1 and as many as 18% of pregnant women take medication to treat this condition 2.Hyperemesis gravidarum (HG) is the most. Up to 80% of pregnant women experience discomfort due to symptoms originating from the gastrointestinal tract; ∼5% of them have more severe disease that can adversely affect maternal and fetal outcome. This review presents options of symptomati Pruritus may be intense and distressing to the mother, thus requiring therapy. Ursodeoxycholic acid (FDA category B) is the treatment of choice for reducing pruritus. It also improves biochemical markers without adversely affecting the mother or the baby. The main risk of ICP is to the fetus
Cholestasis is defined as a reduction or stoppage in the flow of bile into the intestine caused either by an extrahepatic cause like a blockage (eg. a stone in the bile duct) or by an intrahepatic cause leading to impaired production of bile, like a liver disease. Cholestasis (Bile Duct Obstruction): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis It is characterized by an initial large round spot on the chest, abdomen, or back, often referred to as a herald patch, that is usually followed within a week by a distinctive pattern of similar but smaller papules on the torso, arms, and legs. There may also be itching, especially when overheated Synonyms for pruritus in Free Thesaurus. Antonyms for pruritus. 5 words related to pruritus: itchiness, itching, itch, pruritus ani, pruritus vulvae. What are synonyms for pruritus Urticaria pigmentosa occurs when there are too many inflammatory cells (mast cells) in the skin. Mast cells are immune system cells that help the body fight infections. Mast cells make and release histamine, which causes nearby tissues to become swollen and inflamed. Urticaria pigmentosa is most common in children